Built at the innermost point of the Pagasetic Gulf and at the foot of Mount Pilio (Pelion, the land of the Centaurs).
The city spreads in the plain on the foothills of Mount Pelion, bordering the town of Agria to the east and Nea Anchialos to the south west.
The Bulgarians plundered Thessalia, from their encampment which was located between modern day Volos and Velestino.
During the Axis occupation of Greece, the prompt actions of the local chief rabbi, Moshe Pessach, and the Greek authorities, saved about 700 of the local Jewish community from deportation to the Nazi death camps.
In the 14 century Volos came under the control of Serbia, subsequent conquest by the Republic of Venice and the Catalans led to a large drop in the local population.
it marked the southern border of the Vilayet-i Rumeli-i Şarki.
In 1882, Andreas Syngros established the Privileged Bank of Epirus and Thessaly, which the National Bank of Greece acquired in 1899 after its founder's death.
Volos was occupied by Ottomans on , during the Greco Turkish War.